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Birth10mm
2years3mm
3years2mm
30yearsClosed
Wormian bones close by 6 months
Metopic suture (dividing frontal bone is usually closed by 2 years, but may persist as a normal variant)



MetabolicRickets, Hypercalcaemia (and Hypervitaminosis D), Hyperthyroidism
HaematologicalSickle Cell, Thalassaemia
DysplasiaHypophosphatasia, Achondroplasia, Hurlers
SyndromesApert, Crouzon (similar to Apert no syndactyly), Carpenter, Crouzon
MicrocephalyAtrophy or Dysgenesis
Post-Shunting














NeurologicalHaemangioblastomas commonly in the cerebellum (40%)
OcularRetinal angiomas (45%)
RenalCysts (75%), Multiple cystic neoplasms (at least 20%), haemangiomas
AdrenalFamilial phaeochromocytoma (15%), extradrenal paragangliomas
PancreasCysts (75%) Cystadenoma/cystadenocarcinoma, cystic islet cell tumours, haemangioblastoma
Epididymis Cystadenoma (characteristic lesion)
LiverLess common involvement with cysts, haemangiomas or adenomas (often coincidental and unrelated)


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Normal 4 chamber MR. Arrow demonstrates the anotomical site of the membranous portion of the interventricular septum which allows a Gerbode defect to cause LV to RA shunting. Note the more apically located tricuspid valve compared to the more basally positioned mitral valve. 








Lesion                                  Characteristic Feature  
__________________________
Astrocytoma
(including Giant Cell variant)
Foramen of Munro
Colloid Cysts Foramen of Munro/3rd Ventricle
Central Neurocytoma Septum pellucidum attachment
Choroid Plexus PapillomaBody/Temp Horn
MeningiomaTrigone
MetastasesTrigone, Choroid Plexus 
Ependymoma4th Ventricle
Subependymoma 4th Ventricle
Epidermoid/Dermoids Fat containing




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DrugsSteroids (particularly if treating SLE), +/- immunosuppressive therapy (look for a transplant kidney)
Connective tissue DisordersSLE, hypercoagulable states (protein S,C deficiencies), Polycythaemia Rubra Vera, rarely RA
AlcoholismHard to identify the independent contribution-lots of people drink!
Post-traumatic Neck of femur fracture
HaemoglobinopathiesSickle Cell, Thalassaemia
Pancreatitis
Caissons disease
GauchersLook for Erlen-Meyer flask deformity
Amyloid

(So my catchy mneumonic would be DCAPHPCGA –almost looks like a gene sequence)





 
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